Overview

Efficacy of Dalbavancin in Osteoarticular Infections Associated With Hip and Knee Replacements

Status:
Not yet recruiting
Trial end date:
2024-09-29
Target enrollment:
0
Participant gender:
All
Summary
Osteoarticular infections associated with hip and knee prostheses require optimal surgical and medical management to maximize the rate of therapeutic success. Antibiotic therapy should be administered for a period of 12 weeks. Tolerance problems, difficulties in maintaining compliance over 12 weeks, bacterial multidrug resistance and sometimes intravenous administration are the main obstacles to appropriate antibiotic therapy and to limiting iatrogenicity. Dalbavancin is an antibiotic derived from teicoplanin (glycopeptide) with a long half-life, of punctual parenteral administration without a central line, active on staphylococci, and well tolerated. The data in the literature concerning its efficacy in Osteoarticular infections associated with hip and knee prostheses are limited and heterogeneous. Investigators would like to describe its efficacy in a homogeneous series of patients in terms of the type of infection, their surgical management and the methods of administration of the product in order to extend its use.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Centre Hospitalier Universitaire de Nice
Treatments:
Dalbavancin
Criteria
Inclusion Criteria:

- Age greater than or equal to 18 years

- First monomicrobial osteoarticular infection of knee or hip prosthesis with
staphylococcus sensitive to dalbavancin (determined by a minimum inhibitory
concentration by microdilution of the strain in question for vancomycin less than or
equal to 2mg/L) and rifampicin, treated surgically by debridement, antibiotics and
implant retention with change of moving parts (acute infections) or change in 1 stage
(chronic infections)

- Social security affiliation

- Signature of informed consent

Exclusion Criteria:

- Hypersensitivity to glycopeptides or rifampin or to any of the excipients

- Porphyrias

- Probabilistic antibiotic treatment not administered within 24 hours of surgery

- Probabilistic antibiotic treatment that did not take into account the bacterium
causing the infection in its spectrum

- Acute hematogenous infection (acute secondary)

- Use of background treatment incompatible with the inducing effect of rifampicin (see
Summary of Product Characteristics for rifampicin)

- Contraindications to rifampin therapy: Moderate to severe impairment of liver
function, patients with a history of hypersensitivity to other rifamycins, porphyria.

Hepatic cirrhosis

- Use of ototoxic therapy, such as an aminoglycoside

- Renal function with glomerular filtration rate less than 30 ml/min as measured by MDRD
(Modification of Diet in Renal Disease)

- Pregnant and breastfeeding women: at inclusion a blood pregnancy test will be
performed for women of childbearing age. The results will be communicated to the
patient by a physician of her choice.

- Women of childbearing age not using an effective method of contraception (pill,
intrauterine device, vaginal ring, contraceptive skin patch, hormonal subcutaneous
implant, surgical sterilization)

- Protected persons defined in the following articles of the public health code:

L. 1121-6: persons deprived of liberty by a judicial or administrative decision, persons
hospitalized without consent and persons admitted to a health or social establishment for
purposes other than research; L. 1121-8: adults subject to a legal protection measure or
unable to express their consent; L. 1122-1-2: persons in emergency situations who are
unable to give prior consent.