Efficacy of Corticosteroids in Reducing the Renal Scarring in Acute Pyelonephritis in Children
Status:
Recruiting
Trial end date:
2024-12-01
Target enrollment:
Participant gender:
Summary
Urinary tract infection (UTI) is the most frequently occurring serious bacterial infection in
young children and accounts 5 to 14% of emergency department visits Formation of renal
scarring in children has been associated with serious complications as hypertension,
preeclampsia, and end stage renal failure in young age . So, this study aims to determine
whether dexamethasone reduces the renal scarring in children will be treated with antibiotics
for acute pyelonephritis.
investigators propose to conduct a multi center, randomized, placebo-controlled, double-blind
clinical trial, that will evaluate the efficacy of dexamethasone (0.3 mg/kg every 12 hours
per day orally for 3 days) in preventing renal scarring in young febrile children (2 months
to 14 years) with a first-diagnosed UTI. 120 Participants will be enrolled over a 3-year
period from 6 sites.