Efficacy of Coordinated Insulin Boluses in Type 1 Diabetic Patients

• Status: Completed
• Trial end date: 2016-11-01
• Target enrollment: 0
• Participant gender: All

Summary

A recent study suggests that, in Type 1 Diabetes (T1D) patients treated by insulin pumps, a better coordination of meal boluses and post prandial basal rate could reduce the importance of postprandial hyperglycaemias without increasing the risk of delayed hypoglycaemias.

The aim of the investigators study is to assess if these results are confirmed in a clinical trial.

The aim of this study is to compare the efficacy of coordinated boluses versus normal boluses on postprandial glycaemic control of T1D patients treated with continuous subcutaneous insulin infusion.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Toulouse
• Treatments: Insulin

Criteria

Inclusion Criteria:

• Type 1 diabetes mellitus

• with confirmed Negative C-peptide or diabetes duration>5 years

• Treated by external insulin pump and rapid insulin analog for more than 3 months

• using a Medtronic Paradigm Real-Time or Veo™ model

• Educated to and practicing functional insulin treatment and carbohydrate counting for more than 3 months

• Able to use the "basal temp" and "glycaemia reminder" functions of their pump

• Basal infusion rate ≥ 0,5 Unit/h

• Self-monitoring of blood glucose frequency > 4/days

• Aware of hypoglycaemia

Exclusion Criteria:

• known impaired renal function (creatinin clearance <60ml/min)

• Gastroparesis

• Serious or instable disease likely to induce a glycaemic control deterioration - treatment with corticosteroids