Efficacy of Combination Therapy for Prevention of Effects of Malaria During Pregnancy
Status:
Completed
Trial end date:
2009-06-01
Target enrollment:
Participant gender:
Summary
This study is an investigation to compare the efficacy of two different intermittent
sulfadoxine/pyrimethamine (SP) treatment regimens and intermittent sulfadoxine/pyrimethamine
(SP) + artesunate (SP/AS) treatment of HIV negative and positive mothers in clearing
placental parasitemia at delivery. If intermittent protective SP/AS treatment is equally
efficacious and safe as intermittent protective SP, such a regimen could be adapted for
programmatic use as a potentially more durable alternative to SP monotherapy in areas of
increasing SP resistance.
Phase:
Phase 4
Details
Lead Sponsor:
Centers for Disease Control and Prevention
Collaborator:
Ifakara Health Research and Development Centre
Treatments:
Artesunate Fanasil, pyrimethamine drug combination Pyrimethamine Sulfadoxine