Efficacy of Colchicine to Prevent Skin Relapses in Adult's IgA Vasculitis
Status:
Recruiting
Trial end date:
2023-05-12
Target enrollment:
Participant gender:
Summary
Immunoglobulin A vasculitis (IgA-V), formerly called Henoch-Schönlein purpura, is an immune
vasculitis. Relapses are frequent (30%) and most of the time cutaneous (90%). Cutaneous
involvement in adults is more severe (haemorrhagic blister or necrotic skin lesions) and more
extensive than in children. Quality of life can be significantly altered by frequent
cutaneous relapses. Colchicine, historically used for gout flares, is known to be an " old "
low cost drug inducing very few adverse events. This molecule inhibits polymorphonuclear
cell-chemotaxis to the site of inflammation explaining colchicine clinical efficacy in
diseases such as Familial Mediterranean Fever or Behçet disease. Efficacy of colchicine has
also been reported in cutaneous leukocytoclastic vasculitis including IgA-V, but without
clinical studies supporting this attitude.