Efficacy of Coadministration of Calcitonin and Hyperbaric Bupivacaine on Spinal Anesthesia in Tramadol-abuse Patients
Status:
Completed
Trial end date:
2021-01-31
Target enrollment:
Participant gender:
Summary
Increasing duration of local anesthetic action is desired for prolongation of postoperative
patient comfort, as well as decreasing perioperative opioid consumption and subsequent side
effects. Calcitonin, discovered in 1961, has been established, synthesized, and developed for
use in treating disease. In 1983 it was demonstrated that calcitonin is an analgesic, which
is also effective in the epidural and subarachnoid spaces.Tramadol abuse has dramatically
increased in Egypt since 2008 and has led to many admissions to addiction treatment
centers.It was shown that the duration of sensory block of spinal anesthesia with hyperbaric
bupivacaine in chronic opium abusers undergoing lower extremity orthopedic surgery was much
shorter in chronic opium abusers compared with non-abusers.