Lower third molar extraction is one of the most common treatments in oral surgery practice.
It is a treatment with inherent complications such as postoperative pain, swelling or
trismus. In order to minimize disconfort after extraction, analgesic and anti-inflammatory
medication is prescribed. Recently, it is seen that circadian rhythm may play an important
role on drugs metabolism, modulating its effect depending on the moment of administration.
The aim of the study is to analyze if dosage modification of a Non Steroideal
Anti-Inflammatory (ibuprofen) affects on postoperative pain, swelling and open mouth
limitation comparing to the normal dosage.