Efficacy of Chloroquine (CQ) Alone Compared to Concomitant CQ and Primaquine for Plasmodium Vivax Infection
Status:
Completed
Trial end date:
2015-09-01
Target enrollment:
Participant gender:
Summary
This is a randomized open-label trial to evaluate the efficacy of chloroquine (CQ) alone
compared to chloroquine+primaquine (CQ+PQ) in the treatment of uncomplicated malaria caused
by Plasmodium vivax infection in a endemic area in the westernmost part of the Amazon Basin
of Brazil. The duration of follow up for evaluating CQ efficacy as a schizonticidal drug was
28 days. The duration of complete follow up to detect recurrent P. vivax infections by
passive surveillance was six months. All patients in the CQ alone arm received 7 days of PQ
treatment (3.5mg/kg total dose) starting on day 28 of the study follow-up.