Efficacy of Baclofen Vs Naltrexon in Achieving & Maintaining Abstinence in Alcohol Dependence.
Status:
Not yet recruiting
Trial end date:
2025-03-31
Target enrollment:
Participant gender:
Summary
ALD is the most common cause of liver cirrhosis in western world. In patients with ALD
persistent alcohol intake is associated with increased mortality while cessation of alcohol
consumption improve survival. Baclofen is GABA-B receptor agonist and it is safe in cirrhotic
patient for alcohol abstinence i.e. already proven and naltrexone is Delta and k-opioid
receptor antagonist and it is safe in cirrhotic for alcohol abstinence i.e, proven in ILBS.