Efficacy of Azelastine and Mometasone Irrigation in Comparison to Nasal Sprays in Patients With Chronic Rhinitis

• Status: Not yet recruiting
• Trial end date: 2026-08-01

Summary

The goal of this clinical trial is to determine the best combination of drugs and drug delivery routes to treat surgically naive chronic rhinitis patients. The main question it aims to answer is:

Do high volume, high pressure delivery mechanisms in nasal irrigation improve the efficacy of azelastine combined with nasal steroid mometasone as compared to the standard low pressure, low volume delivery mechanisms in nasal sprays?

Subjects will complete six months of one of three medication regimens:

1. saline irrigation followed by azelastine spray and mometasone spray

2. mometasone saline irrigation

3. azelastine saline irrigation combined with mometasone saline irrigation.

• Phase: Phase 4

Details

• Lead Sponsor: NorthShore University HealthSystem
• Treatments: Azelastine; Mometasone Furoate