Efficacy of Antiviral Medications in Controlling Vertigo Attacks of Patients With Meniere's Disease
Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
Meniere's disease is a chronic illness that affects a substantial number of patients every
year worldwide. The disease is characterized by intermittent episodes of vertigo lasting from
minutes to hours, with fluctuating sensorineural hearing loss, tinnitus, and aural pressure.
It has recently been suggested that viral etiologies specially Herpes virus might be the
underlying reason. The investigators study is a randomized, double- blinded
placebo-controlled clinical trial in Amiralam Hospital. In this study the primary objective
is to assess efficacy of Acyclovir in control of symptoms in patients with Meniere's disease
specially their vertigo attacks. Inclusion criteria would be patient's willingness to
participate in the study and follow ups, being 18 years old or older, having at least 2
vertigos per month each at least 20 min, interfering with function, and not on medication for
Meniere's disease for at least 3 months before the trial. They should not have any history of
allergy to Acyclovir, renal insufficiency or Creatinine above 1.5 mg/dl, hepatic enzymes more
than three times normal, serious uncontrolled illness, be pregnant or nursing or have
previous surgeries on Endolymphatic Sac. Participants will be randomly placed in 2 different
arms getting either Acyclovir 400 mg or placebo (inert ingredient). They will take the
medication for 10 days 5 times a day, then 3 times a day for next 10 days, and 2 times a day
for the last 10 days. Patients will report changes in their symptoms 10 days after initiating
the drug and in 1, 3, 6 month intervals.