Efficacy of Antituberculous Therapy in Management of Sarcoidosis
Status:
Completed
Trial end date:
2013-03-01
Target enrollment:
Participant gender:
Summary
From the time sarcoidosis has been described, there has always been a belief that the disease
is in some way related to tuberculosis. If indeed tuberculosis is a causal factor in
sarcoidosis, then the hypothesis can be further reinforced, if anti-tubercular therapy (ATT)
is useful in treatment of sarcoidosis. Very few trials have been conducted in the past but
the results of these trials have been discouraging. These trials were generally small studies
and limited by time bias and used older regimens based on isoniazid, amino-salicylic acid and
streptomycin. In our experience nearly one third of patients who are finally diagnosed to
have sarcoidosis, have received ATT for variable length of time, but its impact of final
outcome of sarcoidosis has not been studied. The aim of this prospective randomized
controlled trial (RCT) is to evaluate the efficacy and safety of Rifampicin and Isoniazid
along with prednisolone compared to prednisolone alone in treatment of Sarcoidosis.
Phase:
N/A
Details
Lead Sponsor:
Postgraduate Institute of Medical Education and Research