Efficacy of Amiloride and Hypertonic Saline in Cystic Fibrosis
Status:
Completed
Trial end date:
2004-04-01
Target enrollment:
Participant gender:
Summary
The purpose of this research study is to determine whether the combination of inhaled
amiloride and a concentrated salt solution is better than the salt solution itself for cystic
fibrosis (CF) patients. In CF, airway secretions are thick and dehydrated. Many patients use
inhaled salt solutions to help draw water into their secretions so that they are easier to
get rid of with chest physiotherapy ("chest PT") and cough. Unfortunately, these salt
solutions are reabsorbed very quickly by the airways, so the beneficial effects may not last
very long. In the hopes of prolonging their effects, the drug amiloride could be used in
combination to slow salt and water reabsorption from airways. Amiloride is a medication that
has been given by mouth for high blood pressure for many years. It is possible that the
combination of salt solutions and inhaled amiloride may significantly improve the clearance
of secretions in CF, which would be expected to improve lung function in CF.
Phase:
Phase 2
Details
Lead Sponsor:
University of North Carolina
Collaborators:
Cystic Fibrosis Foundation Cystic Fibrosis Foundation Therapeutics