Efficacy of Adjusted Clopidogrel Dose in Patients With Insufficient Platelet Inhibition

• Status: Completed
• Trial end date: 2006-06-01
• Target enrollment: 0
• Participant gender: All

Summary

This study is a prospective, single-center evaluation of the efficacy of clopidogrel dose adjustment in patients with insufficient platelet inhibition after elective coronary stent implantation.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Heart Center Bad Krozingen; University Heart Center Freiburg - Bad Krozingen
• Treatments: Clopidogrel; Ticlopidine

Criteria

Inclusion Criteria:

• Patients undergoing elective coronary stenting

• Pretreatment with a bolus dose of 600mg of clopidogrel at least 2 hours prior to coronary stent implantation

• Pretreatment with aspirin ≥ 100 mg per day for at least 7 days

• Age > 18 years

• Written consent

Exclusion Criteria:

• Troponin T on admission > 0.03 ng/mL

• Myocardial infarction or fibrinolytic therapy within the previous 14 days

• Cardiogenic shock

• Contraindication for aspirin or clopidogrel

• Oral anticoagulation

• Pretreatment with heparin or a thienopyridine within the previous 14 days

• Use of a GP IIb/IIIa-receptor antagonist during PCI

• Platelet count < 100.000/µl

• Severe disorders of the coagulation system

• Severe impairment of liver or kidney function

• Cancer