Overview

Efficacy of Adding Topiramate to Current Treatment in Refractory Obsessive Compulsive Disorder (OCD)

Status:
Completed
Trial end date:
2019-01-01
Target enrollment:
0
Participant gender:
All
Summary
SRI's are considered first-line treatments for OCD, however many patients continue to have significant symptoms despite an adequate trial of an SRI. Neuroimaging studies have shown that the glutamate neurological system is involved in OCD. This study will test the safety and efficacy of topiramate, a drug, which targets glutamate, in the treatment of OCD, where the OCD has been un-responsive, or partially responsive to regular SRI treatment.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Hamilton Health Sciences Corporation
McMaster University
Collaborators:
Hamilton Health Sciences Corporation
Janssen-Ortho Inc., Canada
Treatments:
Serotonin Uptake Inhibitors
Topiramate
Criteria
Inclusion Criteria:

- Outpatient with primary DSM- IV OCD

- Completion of a 14-week open label trial of one the following SRI's: fluoxetine 80
mg/day, paroxetine 60 mg/day, fluvoxamine 300 mg/day, clomipramine 250 mg/day,
sertraline 200 mg/day, citalopram 60 mg/day, escitalopram 30 mg/day and demonstrating
a non or partial responses to SRI treatment (CGI-I of 3 or 4, Y-BOCS reduction of <
35%)

- Stable (8 wks or longer) concurrent medications including benzodiazepines, sedative
hypnotics, antipsychotics, and antidepressants.

Exclusion Criteria:

- Any other primary DSM-IV diagnosis; DSM-IV criteria for body dysmorphic disorder,
bipolar affective disorder, schizophrenia, psychotic disorder, current
alcohol/substance abuse.

- A previous adequate trial of topiramate

- Comorbid major depressive disorder diagnosis which predates OCD diagnosis

- Cognitive behavioural therapy or additional psychotherapy in past four months

- Allergy or hypersensitivity to topiramate

- BMI < 20

- History of kidney stones