Efficacy of 17 Alpha-hydroxyprogesterones Caproate for the Prevention of Preterm Delivery
Status:
Completed
Trial end date:
2010-05-01
Target enrollment:
Participant gender:
Summary
To demonstrate that the intramuscular administration of 17 alpha hydroxyprogesterones
caproate allows to reduce the risk of preterm delivery, in 3 high risk populations defined by
the association of an ultrasonographic cervical length egal and inferiority 26 mm between 20
and 32 weeks of gestation and:
- either a first episode of preterm labor stopped by acute tocolysis;
- either a history of late miscarriage or premature delivery or uterine malformation or
DES
- either a twin pregnancy. Therefore, a randomised, multicentre trial has been designed
with initial stratification according to these three risk groups, opened with two
parallel arms.