Overview

Efficacy and Tolerability of Switching to Ziprasidone From Other Antipsychotics

Status:
Completed
Trial end date:
2008-04-01
Target enrollment:
0
Participant gender:
All
Summary
Because ziprasidone has not been extensively studied and is not widely accepted in the severely mentally ill in State hospitals this study aims to demonstrate its effectiveness and relative lack of side effects. 75 patients with schizophrenia or schizoaffective disorder who need a change of medication because of ineffectiveness or side effects will be changed to ziprasidone and followed with detailed assessments for eight weeks. The hypothesis is that they will improve and have fewer side effects.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Bronx Psychiatric Center
Collaborators:
Buffalo Psychiatric Center
Pfizer
Rochester Psychiatric Center
Treatments:
Antipsychotic Agents
Ziprasidone
Criteria
Inclusion Criteria:

- Schizophrenia or schizoaffective

- Capacity to give consent

- Stable, on the same medication for a month but only partial response or with
unacceptable side effects 18-65 years of age

Exclusion Criteria:

- Repeated non-compliance

- Current depot medication

- Active medical conditions

- QTc >500msec

- Previous non-response

- Previous treatment with ziprasidone