Efficacy and Safety of a Therapy Change From Candesartan 32 mg to Fixed Combination of Olmesartan 40 mg/Amlodipine 10 mg
Status:
Completed
Trial end date:
2013-01-01
Target enrollment:
Participant gender:
Summary
The investigators want to find out if a treatment with a new combination of two different
antihypertensive drugs (olmesartan and amlodipine) in one tablet in patients with moderately
elevated blood pressure is more effective than treatment with just one substance
(candesartan). All antihypertensive treatment will be ceased for two weeks to achieve
comparable baseline conditions. Treatment is then started with the single substance. After
six weeks, therapy is changed to another single substance and after a further six weeks, to
the fixed combination tablet. Blood pressure is determined by office measurements taken by
the doctor and via long-term ambulatory blood pressure monitoring (ABPM). Participants may be
male or female and must be over 18 years of age.