Efficacy and Safety of Valsartan Plus Hydrochlorothiazide in Patients With Slight Hypertension and Target Organ Damage
Status:
Completed
Trial end date:
2008-12-01
Target enrollment:
Participant gender:
Summary
Patients with slight increase in blood pressure levels have an increased cardiovascular risk.
In particular this has been demonstrated also in subjects with high-normal blood pressure in
whom an exaggerated blood pressure increase, during exercise, and structural left ventricular
abnormalities have been shown. On the other hand, the last American and European guidelines
for management of hypertension recommend more aggressive treatment in young-middle aged
subjects to achieve a better control of cardiovascular risk due to blood pressure increase.
In agreement with these recommendations the investigators share the idea that a good blood
pressure control should be achieved not only at rest, but also during psycho-physical stress
conditions that frequently occur during daily life. On this basis, the investigators decided
to evaluate the efficacy and tolerability of the association of valsartan and
hydrochlorothiazide (160 an 25 mg daily, respectively) in patients with high-normal blood
pressure and first degree arterial hypertension with evidence of organ damage.
The aim of this study is to assess if an early and adequate therapy could bring to a better
pressure control (even during physical activity) and a regression of organ damage without
interfering with metabolism and erectile function