Overview

Efficacy and Safety of Total Glucosides of Paeony Combined With NB-UVB on Treating Vitiligo

Status:
Completed
Trial end date:
2019-07-31
Target enrollment:
0
Participant gender:
All
Summary
1. Total Glucosides of Paeony(TGP) As a traditional Chinese medicine, peony root is the dried root of peony of Ranunculaceae, cultivated all over the country.The main ingredient is a group of glycosides, including paeoniflorin, hydroxy paeoniflorin, paeoniflorin, paeoniflorin, benzoyl paeoniflorin etc, collectively referred to as total glucosides of paeony(TGP). Paeoniflorin accounted for more than 90% of the TGP, is the main active ingredient of white peony root.By pharmacological and clinical studies of TGP, it have found that the mechanism of TGP is unique and mainly acts on the upstream of the immune response - inhibiting the presentation of antigens. It is different from immunosuppressive agents on T, B lymphocytes, or hormones and other drugs acting on the whole process. 2. Vitiligo Vitiligo is a pigment deprived skin disease caused by the destruction of melanocytes, the global incidence of about 1%. The pathogenesis is not yet clear, the current study shows that oxidative stress and autoimmunity is an important part of its occurrence and development. 3. The basic and clinical research of TGP used in vitiligo The ratio of cluster of differentiation 4+ / cluster designation 8+ T cell vs. cluster of differentiation 4+ chronotropic dose 25+ in the peripheral blood of patients with vitiligo could be significantly increase, after patients treatment by TGP combined with tacrolimus. Thereby enhancing the patient's maintenance of immune self-stability and Immune tolerance ability, promoting the healing of skin lesions. It showed significant effect in stable vitiligo,when patients treated by autologous epidermal grafting combined with TGP.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
xjpfW
Collaborators:
Air Force General Hospital of the PLA
Chinese Academy of Medical Sciences
First Hospital of China Medical University
Criteria
Inclusion Criteria:

- subjects must be clinically diagnosed by the investigator to have sporadic Vitiligo in
proceeding

- Vitiligo with at least 3 depigmented areas in different anatomy areas including:1%~50%
of the total body surface area (BSA) in (face /trunk/limbs),the minimum area is
greater than 1 cm2 .Males or females, 18 Years to 65 Years of age at the time of
signing the informed consent document.

.Understand and voluntarily sign an informed consent document prior to any study related
assessments/procedures being conducted.

Exclusion Criteria:

- Actively spreading vitiligo,or stable vitiligo;

- Subjects with segmental, acromegaly, mucous, generalized, mixed and undetermined
vitiligo.;

- Secondary vitiligo subjects with history of UV photosensitivity

- Subjects with other diseases unsuitable for ultraviolet light therapy and TGP ; .Use
of vitiligo topical drugs within 2 weeks or, system treatment and phototherapy for the
treatment of vitiligo within four weeks.

- History of allergy to any component of the total glucosides of paeony(TGP);

- Subjects with a history of chronic diarrhea or peptic ulcer within 1 year .Women who
are pregnant or breast feeding,or preparing for pregnancy. .Subjects with serious
medical diseases or history of mental system abnormal. .Use of any prior and
concomitant therapy not listed above that may interfere with the objective of the
study as per discretion of the investigator.