Efficacy and Safety of Single, Low-dose Dexamethasone in Patients After Total Knee Arthroplasty

• Status: Completed
• Trial end date: 2012-01-01
• Target enrollment: 0
• Participant gender: All

Summary

This study was conducted to determine the efficacy of an additional preemptive, single, low-dose dexamethasone in terms of incidence and severity of postoperative nausea/vomiting (PONV), pain level, and the safety in terms of wound complications in patients managed with our antiemetic protocol based on Ramosetron following TKA.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Tae Kyun Kim
• Treatments: BB 1101; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate

Criteria

Inclusion Criteria:

• Diagnosis of primary osteoarthritis, knee

• Scheduled for elective total knee arthroplasty

• Signed written informed consent

Exclusion Criteria:

• Refusing participate

• Contraindication to regional anesthesia

• Severe impairment of bowel motility

• administration of other antiemetic drug within 24hours before surgery

• systemic steroid within 24hours before surgery

• history of cardiovascular & respiratory disease

• renal & hepatic failure