Efficacy and Safety of Propionibacterium Extract Gel Versus 0.4% Glyceryl Trinitrate Ointment in the Treatment of Chronic Anal Fissure: a Randomised Controlled Trial

• Status: Completed
• Trial end date: 2022-05-31
• Target enrollment: 0
• Participant gender: All

Summary

The study compares the efficacy and safety of a Propionibacterium extract gel with 0.4% glyceryl trinitrate ointment in the treatment of chronic anal fissure.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Treviso Regional Hospital
• Treatments: Nitroglycerin

Criteria

Inclusion Criteria:

• Consecutive patients diagnosed with chronic anal fissure aged between 18 and 75 years

Exclusion Criteria:

• Fecal incontinence

• Inflammatory bowel disease

• Previous history of anal surgery

• Previous or concomitant treatment for anal fissure, sexually transmitted disease, cancer, immune-suppressive treatment

• Current pregnancy or breastfeeding

• Known allergy to one of the agents contained into the evaluating drugs