Efficacy and Safety of Peri-operative Pregabalin After Radical Cystectomy

• Status: Completed
• Trial end date: 2015-11-01
• Target enrollment: 0
• Participant gender: All

Summary

This study compares analgesic efficacy, and safety of three different doses of peri-operative pregabaline to placebo following radical cystectomy.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assiut University
• Treatments: Pregabalin

Criteria

Inclusion Criteria:

• Sixty patients between the ages of 18 and 60 years.

• American Society of Anesthesiologists (ASA) I-II physical status.

• undergoing radical cystectomy under general anesthesia.

Exclusion Criteria:

• Patients with a history of drug or alcohol abuse.

• patients with chronic pain or daily intake of analgesics.

• uncontrolled diabetes mellitus.

• uncontrolled hypertension.

• atherosclerotic heart disease.

• seizures.

• impaired kidney or liver functions,

• patients with body mass index ≥35 kg/m2, and whom

• patients that could not control a patient controlled analgesia (PCA) device.