Efficacy and Safety of Parecoxib on Morphine Patient-controlled Epidural Analgesia (PCEA) After Gynecologic Surgery

• Status: Completed
• Trial end date: 2010-05-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to determine the effects of parecoxib in combination with epidural morphine in providing analgesia for patients undergoing gynecological surgery.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Liu Weifeng
• Collaborators: Guangdong General Hospital; Guangdong Provincial People's Hospital; Nanfang Hospital of Southern Medical University; Second Affiliated Hospital, Sun Yat-Sen University
• Treatments: Morphine; Parecoxib

Criteria

Inclusion Criteria:

• women scheduled for elective gynecological surgery under combined spinal-epidural anesthesia

Exclusion Criteria:

• contraindications for CSE placement

• known allergy, sensitivity, or contraindication to opioid and nonopioid analgesic drugs

• history of bleeding disorders, peptic ulceration, or anticoagulant use within the past month

• current pregnancy or breastfeeding

• history of known or suspected drug abuse

• unable to understand the use of pain assessment scales and the PCA device

• Patient with asthma or bronchospasm, requiring treatment with glucocorticoids

• poorly controlled hypertension or diabetes, a chronic or acute renal or hepatic disorder, or inflammatory bowel disease

• patients had taken antidepressants, narcotic analgesics, antihistamines, anxiolytics, hypnotics, sedatives, NSAIDs, or corticosteroids up to 24 h before receipt of the study medication