Efficacy and Safety of Modified Gegen Qinlian Decoction for Diarrhea-predominant Irritable Boewl Syndrome
Status:
Recruiting
Trial end date:
2023-12-31
Target enrollment:
Participant gender:
Summary
Diarrhea-predominant irritable boewl syndrome(IBS-D) seriously affect the quality of life in
patients. Clinically, it is effective to apply therapeutic method of clearing heat and
promoting diuresis to the common syndrome of dampness-heat. Dysbiosis of intestinal
microbiota is closely related to the immune imbalance and intestinal mucosal barrier injury.
C1orf106/CYTH-1/ARF6 signal pathway, which derive from intestinal micro environment
changes,is the mainly cause of intestinal mucosal barrier injury, and this is may be the
common pathogenesis of dampness-heat syndrome in IBS-D . Based on the clinic, the project is
to study the effect and mechanism of Chinese compound formula of clearing heat and promoting
dieresis in modulating intestinal microbiota dysbiosis, repairing intestinal mucosal barrier
and reconstructing intestinal microenvironment. With the combination of metagenomics and
metabonomics, the study compare the differences of co-metabolites of intestinal microbiota
and host within the healthy people, IBS-D patients with dampness-heat syndrome, to explore
the relevance between intestinal flora and host co-metabolites. Furthermore, the experimental
study is to clarify the drug targets via C1orf106/ CYTH-1/ARF6 signal pathway.Through the
study of association between dampness-heat syndrome in IBS-D and intestinal microbiota, it is
of important academic significance to reveal the Chinese theory intension of "homotherapy for
heteropathy ".
Phase:
Early Phase 1
Details
Lead Sponsor:
Xiyuan Hospital of China Academy of Chinese Medical Sciences