Overview Efficacy and Safety of MTX-loaded Nanoparticles to Treat Severe COVID-19 Patients Status: Not yet recruiting Trial end date: 2020-11-30 Target enrollment: Participant gender: Summary The aim of this study is to evaluate the efficacy and safety of MTX-loaded nanoparticles in three different doses to treat severe COVID-19 patients. Phase: Phase 1/Phase 2 Details Lead Sponsor: Azidus BrasilCollaborators: Hospital Santa MarcelinaInCor Heart InstitutePrevent Senior InstitutePREVENT SENIOR PRIVATE OPERADORA DE SAÚDE LTDATreatments: Methotrexate