Efficacy and Safety of G-CSF in Patients With Severe Alcoholic Hepatitis With Null or Partial Response to Steroid
Status:
Recruiting
Trial end date:
2022-12-01
Target enrollment:
Participant gender:
Summary
Steroid is the treatment of choice in patients with severe alcoholic hepatitis. However,
null- or partial responder of steroid treatment is recommended to consider liver
transplantation. The yearly demand for liver transplants far exceeds the supply of available
organs and alcoholic liver disease has been a controversial indication for transplantation.
Granulocyte-Colony Stimulating Factor (G-CSF) has been reported to have effect of
proliferation of hepatic progenitors in alcoholic steatohepatitis. The aim of this study is
to investigate the efficacy of G-CSF in patients with severe alcoholic hepatitis with null or
partial response to steroid.