Efficacy and Safety of 0.25% Timolol Gel in Healing Surgical Open Wounds

• Status: Active, not recruiting
• Trial end date: 2021-06-30
• Target enrollment: 0
• Participant gender: All

Summary

The use of topical beta-blockers, such as 0.25% timolol, in promoting wound healing is currently emerging in the academic literature. The investigators will enroll 114 patients who have their skin cancer surgically removed resulting in open surgical wounds less or equal to 1.5 cm. The objective of this randomized safety study is to determine the safety and efficacy of 0.25% timolol in promoting wound healing in open surgical wounds less or equal to 1.5 cm.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Brigham and Women's Hospital
• Treatments: Petrolatum; Timolol

Criteria

Inclusion Criteria:

1. Age greater than 18 years

2. Open surgical wound ≤1.5cm

3. No hypersensitivity with use of 0.25% timolol gel

Exclusion Criteria:

1. Age less than 18 years of age

2. Open surgical wound >1.5cm

3. Pregnant women

4. Use of systemic retinoids within 1 month

5. Any hypersensitivity with use of 0.25% timolol gel