Efficacy and Safety Study of Avastin to Treat Neovascularisation of the Cornea

• Status: Completed
• Trial end date: 2019-10-01
• Target enrollment: 0
• Participant gender: All

Summary

Corneal newvessels may arise from a fan of pathologies, inducing long-standing corneal opacification requiring keratoplasty. These last years, VEGF inhibitors have been designed to reduce newascularization induced by gastric cancer or age-related macular degeneration. A few reports have been published showing the interest of VEGF inhibitors to treat corneal newvessels, but no randomized study has been achieved to date.

This study is designed to assess the efficacy of Bevacizumab, a VEGF inhibitor monoclonal antibody, to reduce the surface of corneal newvessels in when compared to placebo

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Limoges
• Treatments: Bevacizumab

Criteria

Inclusion Criteria:

inclusion criteria:

• Patients with corneal neovascularization whatever the origin

• Patient did not receive treatment with topical corticosteroids during the month preceding inclusion.

• Patient who has been properly informed and signed consent

• Patient aged over 18

• Patient affiliated with a health insurance plan or benefit of such a regime

Exclusion Criteria:

• Patients who received local or general treatment of concomitant prostaglandin derivatives

• Patients with current infection of the cornea or other tissue / organ

• Women of childbearing age without contraception

• Pregnancy and Lactation

• Patient participating in another study

• Patient with contact lenses

• Patients with uncontrolled hypertension

• Patient with a history of stroke, myocardial infarction, angina pectoris, thrombophlebitis, Raynaud's phenomenon.

• Patients hypersensitive to the active substance or any excipients

• Patients hypersensitive to products of Chinese hamster ovary cells or other recombinant human or humanized antibodies.

• Patients with active bacterial eye infections, fungal, parasitic or viral infection (with the exception of herpes)