Efficacy and Safety Between Different Dilution of Insulin
Status:
Recruiting
Trial end date:
2024-12-31
Target enrollment:
Participant gender:
Summary
Hyperglycemia associated with insulin resistance is common in critically ill patients, even
in those nondiabetic patients. Hyperglycaemia or relative insulin deficiency (or both) during
critical illness may directly or indirectly confer a predisposition to complications, such as
severe infections, polyneuropathy, multiple-organ failure, and death. Tight glycaemic control
in adult long-stay critically ill patients using intensive insulin therapy reduces absolute
mortality. It has been reported that pronounced hyperglycemia may lead to complications in
such patients, although data from controlled trials are lacking. However, target glycaemia
may be difficult to achieve in clinical practice. Insulin adsorption onto infusion equipment
(e.g., infusion tubing) may affect glucose control, possibly leading to hyperglycemia. In the
use of low-level intravenous insulin infusion for treating diabetic hyperglycaemia and
ketoacidosis adsorption of insulin to containers or plastic infusion apparatus results in
significant losses of 60-80% of insulin in dilute physiological saline solution.
Problem statement & Study rationale
Up to my knowledge, there is no study that demonstrate differences between types of dilution
for insulin infusion in ICU patient in Malaysia; thus, this study is aimed to evaluate it. In
2001 it has been reported that intensive insulin therapy (IIT) in surgical intensive care
unit (ICU) patients was associated with reduction in mortality and morbidity as well as other
associated factors. There is limited study in comparing dilution of insulin in normal saline
and other types of diluents.
Other than that, it is important to know which diluent the best is to choose for the
management of hyperglycaemia in ICU patient.