Efficacy and Mortality of a Loading Dose of Colistin in Critical Ill Patients

• Status: Unknown status
• Trial end date: 2018-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The study hypothesis is that the loading dose of intravenous colistin (6 million of international units) is associated with greater clinical and microbiological efficacy, and reduced mortality of critically ill patients infected by multidrug resistant Gram- negative bacilli, compared to a scheme without loading dose.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hospital Barros Luco Trudeau
• Collaborator: Fondo Nacional de Desarrollo Científico y Tecnológico, Chile
• Treatments: Colistin; Polymyxins

Criteria

Inclusion Criteria:

• patient hospitalized in critical care units

• patient infected by multi drug resistant Gram negative bacteria susceptibly only to colistin

• source of infection: blood, respiratory, intra abdominal or urinary

Exclusion Criteria:

• pregnant or breastfeeding patients

• patient with a history of hypersensitivity to colistin