Efficacy and Effectiveness of Combined Therapy for Uncomplicated Malaria Treatment in Peru
Status:
Completed
Trial end date:
2008-03-01
Target enrollment:
Participant gender:
Summary
This is a study of the efficacy and effectiveness of combination therapy for malaria due to
P. falciparum in the Loreto Department, Iquitos, Peru. The investigators will enroll subjects
≥ 1 year-old who have a diagnosis of uncomplicated malaria due to P. falciparum. Patients
will receive a treatment regimen consisting of mefloquine (25 mg/kg per day for two days) and
artesunate (12 mg/kg per day for three days). Patients will be divided into two groups: one
will receive drugs under direct supervision and the other will be instructed on how to take
the drugs by themselves. Clinical and parasitologic response will be monitored for a
follow-up period of 28 days. The findings of this study will be used to guide the Ministry of
Health in evaluating its national policy for P. falciparum malaria treatment.