Efficacy and Akathisia Incidence of Slow Infusion Metoclopramide
Status:
Completed
Trial end date:
2008-05-01
Target enrollment:
Participant gender:
Summary
Study Objective:
The purpose of this study is to compare the effects of metoclopramide administration in bolus
versus slow infusion medications in ED patients complaining of nausea for the determination
of the therapeutic effect and prevention of akathisia.
Methods:
This was a prospective, randomized, double-blind trial. The investigation was held between 01
March 2007 and 01 May 2008, in the Emergency Department of Pamukkale University Faculty of
Medicine. The patients with moderate to severe nausea randomized and divided into two groups
as for the previously planned administration type of drug. Ten mg metoclopramide was
administered in one group with slow infusion (SIG) in 15 minutes, via 2 minutes bolus
infusion (BIG) into the other group. Whole procedure was observed, akathisia and nausea
scores and vital changes were recorded.