Efficacy Study of Neridronate to Treat Painful Osteoarthritis of the Knee With Bone Marrow Lesions.

• Status: Unknown status
• Trial end date: 2013-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether neridronate is effective in the treatment of pain related to bone marrow oedema in patients with osteoarthritis of the knee.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: ASST Gaetano Pini-CTO

Criteria

Inclusion Criteria:

• Clinical diagnosis of knee Osteoarthritis (ACR criteria)

• Radiographic diagnosis of knee Osteoarthritis (Kellgren/Lawrence scale >=2)

• >4 weeks but <3 months pain, reported as >30 mm on a 100 mm VAS scale

• bone marrow oedema of the affected knee on magnetic resonance

Exclusion Criteria:

• inflammatory arthritis

• aseptic osteonecrosis of the knee

• previous or current treatment with Bisphosphonates

• serum calcium or creatinine abnormalities