Efficacy Study of Nebulized Morphine and Intravenous Morphine in Post Traumatic Pain

• Status: Completed
• Trial end date: 2014-07-01
• Target enrollment: 0
• Participant gender: All

Summary

In the emergency department, 60% of patients have an acute pain. Appropriate management of acute pain is a public health priority according to who recommendations. Nebulized morphine has been extensively studied in children but less well in adults.

It offers a non-invasive route for systemic drug delivery, more rapid and less invasive than intravenous (IV) method.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Monastir
• Treatments: Morphine

Criteria

Inclusion Criteria:

• Post-traumatic pain with visual analog pain scale( VAPS) ≥ 50%

• Age between 8 and 50 years.

Exclusion Criteria:

• Glasgow coma scale (GCS)< 14,

• Severe injury ,

• Hypotension : blood systolic pressure < 90 mmhg,

• Bradypnea < 12 cpm or SaO2< 90%,

• Chronic pain treatment,

• Aspirin or paracetamol treatment within 6 hours of emergency presentation,

• Nasal trauma, rhinitis, nasal obstruction,

• Incapacity to cooperate,

• Opiate allergy,

• Drug addiction,

• Pregnancy, breast feeding,

• Severe renal and liver failure and chronic obstructive pulmonary disease(COPD)