Efficacy Study of Mirtazapine to Treat Interferon-related Depression During Antiviral Therapy for Hepatitis C

• Status: Terminated
• Trial end date: 2018-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate the anti-depressive efficacy of mirtazapine in depression induced by peginterferon alpha-2a and ribavirin treatment in Korean patients with chronic hepatitis C.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Seoul National University Boramae Hospital
• Treatments: Antiviral Agents; Interferons; Mianserin; Mirtazapine

Criteria

Inclusion Criteria:

• Major depressive episode diagnosed with Diagnostic and Statistical Manual Diploma in Social Medicine-IV (DSM-IV)

• Hamilton Depression Scale (HAMD-17) ≥ 14

Exclusion Criteria:

• Any other axis I primary diagnoses except major depressive disorder

• Having serious adverse events or hypersensitivity to mirtazapine

• Having major depressive disorder prior to the first injection of interferon