Efficacy Study of Leflunomide to Treat Juvenile Idiopathic Arthritis

• Status: Unknown status
• Trial end date: 2014-12-01
• Target enrollment: 0
• Participant gender: All

Summary

A randomized double blind clinical trial to assess efficacy of leflunomide in treatment of refractory juvenile idiopathic arthritis.

Patients are randomly divided into two groups. In group 1 leflunomide and in group 2 placebos will be added to conventional treatment for three months. therapeutic responses will be evaluated by ACRpedi (American College of Rheumatology Pediatric) scores every 4 weeks.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mashhad University of Medical Sciences
• Treatments: Leflunomide

Criteria

Inclusion Criteria:

• JIA based on ACR criteria

• age between 2- 19 y

• polyarticular, oligoarticular(> or = 3 active joints) or extended oligoarticular subtypes

• resistance to conventional treatment

Exclusion Criteria:

• pregnancy

• malignancy

• severe active infection

• other rheumatic diseases or overlap

• ALT(Alanine transaminase) or bilirubin > 3 folds

• IVIG (Intravenous immunoglobulin) treatment during last 2 weeks

• biologic agents during last 3 months