Efficacy Study of Auriclosene Irrigation Solution on Urinary Catheter Patency
Status:
Unknown status
Trial end date:
2016-01-01
Target enrollment:
Participant gender:
Summary
Long-term indwelling urinary catheters are associated with chronic recurrent urinary tract
infections and blockage caused by crystalline biofilm accumulation (encrustation) of the
catheter surfaces. When the urine and catheter are colonized by urease-producing bacteria
such as Proteus mirabilis, encrustation of the catheter is likely to occur.
The use of a catheter irrigation solution that can prevent biofilm formation and encrustation
leading to blockage may keep the catheter patent longer, resulting in fewer catheter changes,
potentially lower incidence of UTIs and better patient quality of life.
Auriclosene is a non-antibiotic, fast-acting, broad-spectrum antimicrobial, which exhibits
potential for the rapid decolonization of a range of urologic pathogens, including the
urease-producing Proteus mirabilis.
Subjects will be randomized to either Auriclosene Irrigation Solution or Auriclosene Vehicle
solution.