Efficacy, Safety Study and Benefit of Alkali Therapy in Sickle Cell Disease
Status:
Terminated
Trial end date:
2019-03-01
Target enrollment:
Participant gender:
Summary
The objective of this study is to assess the effect of alkali administration on bicarbonate
and potassium levels in patients with Sickle Cell Disease (SCD) and depressed serum
bicarbonate levels. The study is a prospective non-blinded evaluation of tolerability and
efficacy of alkali repletion with 4 weeks of observation and two sequential 4 week courses of
escalating oral sodium bicarbonate treatment.