The purpose of the study is to determine the efficacy of Advantage Anti-Caries Varnish.
Single-center, double-blind, controlled Phase 2 study with parallel groups of children.
Subjects will be stratified by early childhood education center and then randomized to
receive either test varnish or control varnish topically to the teeth. Treatment will be
administered quarterly for up to 24 months. The primary outcome is surface-level primary
molar caries increment (d2-4mfs) at 24- months post baseline.