Efficacy Assessment of Systematic Treatment With Folinic Acid and Thyroid Hormone on Psychomotor Development of Down Syndrome Young Children

• Status: Completed
• Trial end date: 2017-12-14

Summary

Evaluation of the following in very young children with Down syndrome:

• the efficacy of systematic treatment with L-thyroxine at controlled doses (clinically and by ultrasensitive thyreostimulating hormone (TSH) assay),

• the efficacy of systematic folinic acid treatment at a dose of 1 mg/kg/o.i.d,

• any interaction between these two treatments.

• Phase: Phase 3

Details

• Lead Sponsor: Institut Jerome Lejeune
• Collaborators: AnticipSante; Ascopharm Groupe Novasco; BIOMNIS; Central Hospital, Nancy, France; Effi-stat; Hôpital Cochin; Inserm U954 (Nancy); LC2; University of Paris 5 - Rene Descartes
• Treatments: Folic Acid; Hormones; Leucovorin; Levoleucovorin