Overview

Efficacies of Two Bismuth Quadruple Therapies in the Second-line Treatment of H Pylori Infection

Status:
Recruiting
Trial end date:
2021-12-31
Target enrollment:
0
Participant gender:
All
Summary
From the profiles of antibiotic susceptibility data following eradication therapy, tetracycline, amoxicillin and levofloxacin are all good candidates of antibiotics used in the rescue treatment.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Ping-I (William) Hsu, M.D.
Treatments:
Amoxicillin
Bismuth
Esomeprazole
Levofloxacin
Ofloxacin
Tetracycline
Criteria
Inclusion Criteria:

- Consecutive H pylori-infected outpatients, at least 20 years of age with failure of
first-line eradication treatments (standard triple, non-bismuth quadruple and bismuth
quadruple therapies)

Exclusion Criteria:

- previous allergic reactions to the study medications,

- history of gastrectomy,

- use of antibiotics within the previous 4 weeks,

- pregnant or lactating women,

- coexistence of serious concomitant illness (for example, decompensated liver
cirrhosis, uremia, and malignancy).