Effects of α MAT Versus Steroid Injection in Knee Osteoarthritis (STα MAT-knee Study)
Status:
Recruiting
Trial end date:
2021-03-31
Target enrollment:
Participant gender:
Summary
Knee Osteoarthritis (OA) is a common degenerative knee condition of the knee which is treated
symptomatically. Knee cartilage tissue has little regenerative ability With the developments
in regenerative medicine, stem cells might also be used in knee OA. Recently, adipose tissue
has been identified as means for autologous mesenchymal stem cells (aMAT) using non-enzymatic
method. Lipogems® is FDA-approved closed-system and directly producing ready-to-use aMAT.
Some observational studies showed its potential in knee chondropathy. With no clinical trial
done as yet, the investigators will hereby study the comparative efficacy of corticosteroid
(current practice) versus Lipogems® in patients with knee OA. The knee MRI changes, clinical
and patient-based outcomes will compared between baseline and throughout till 6 months after
treatment. This study aims to show the comparative efficacy of Lipogems® as compared to
corticosteroid in knee OA patients and to demonstrate its cartilage regeneration potential,
which will ultimately deter surgery.