Overview Effects of a Tissue Selective Estrogen Complex (TSEC) on Depression and the Neural Reward System in the Perimenopause" Status: Suspended Trial end date: 2021-12-01 Target enrollment: Participant gender: Summary Using neuroimaging, the investigator will study the effects of estrogen on mood and brain function in perimenopausal women with depression. Phase: Phase 4 Details Lead Sponsor: University of North Carolina, Chapel HillCollaborator: Foundation of Hope, North CarolinaTreatments: BazedoxifeneEstrogensEstrogens, Conjugated (USP)