Effects of a Mixed Chinese Herbal Formula on Atopic Dermatitis
Status:
Not yet recruiting
Trial end date:
2025-07-31
Target enrollment:
Participant gender:
Summary
The aim of this study is to investigate the clinical therapeutic effects of a mixed Chinese
herbal formula (CHF) in treating atopic dermatitis (AD) based on its effects on cytokine
levels and immune cell counts. Th1/Th2/Th17/Th22-related cytokines will be assayed to
determine the mechanisms of the anti-inflammatory and immunomodulatory effects of the mixed
CHF in AD patients. The nature of the microbiome dysfunction underlying this disease will be
explored. Investigators will also apply a metabolomics approach to reveal the plasma
metabolites in AD patients of different TCM patterns as well as to monitor changes of plasma
metabolome in AD patients under mixed CHF treatment, aiming to develop metabolic
biosignatures for efficacy of mixed CHF in AD patients exhibiting specific TCM pattern. PK
study will be conducted to exam blood concentration of the prescription in healthy volunteers
and AD patients with good or poor drug response. The results will provide evidence for the
precision treatment based on different TCM pattens of AD patients. Completion of this
integrated project will provide innovative information for future clinical applications.
Phase:
Phase 3
Details
Lead Sponsor:
Chang Gung Memorial Hospital
Collaborators:
National Yang Ming University Taipei Medical University Taipei Veterans General Hospital, Taiwan