Effects of a Combination of IV-PCA With Continuous IV Infusion of MO, Versus IV-PCA MO on Postoperative Pain
Status:
Unknown status
Trial end date:
2010-06-01
Target enrollment:
Participant gender:
Summary
After major surgery, such as abdominal or thoracic surgery, the majority of patients
experience moderate to severe pain that may not be optimally controlled. Inadequate pain
relief may lead to complications that can hinder rehabilitation and slow recovery. Morphine
(MO) is the most commonly used opioid for the treatment of post-surgical pain (14). The
preferred method of administration nowadays is intravenous patient-controlled analgesia
(PCA). In contrast, Continuous infusion of intravenous morphine (CIVM) is seldom used in
Post-Anesthesia Care Units (PACUs) for acute postoperative pain, due to concerns of
cardio-respiratory deterioration, even though different studies have found this technique of
administration effective and safe (in terms of opioid-related symptoms.As part of our efforts
to improve postoperative pain management in the Tel Aviv Sourasky Medical Center's PACU, we
wish to determine if combining CIVM with IV PCA will be superior over IV PCA only for the
treatment of postoperative pain following major abdominal or thoracic surgery.Our hypothesis
is that the continuous infusion, even if given at a relatively low dose, would enable the
build-up of pharmacologically effective MO blood level, thus providing an overall better
control of pain.