Effects of Xiidra on Closed Eye Tear Film Leukocytes in Dry Eye Disease
Status:
Withdrawn
Trial end date:
2019-01-30
Target enrollment:
Participant gender:
Summary
Every night during sleep, there is an accumulation of white blood cells in the closed eye.
The closed eye white blood cells are predominantly neutrophils, but there is a small
population (3%) of T cells. The effects of these closed eye white blood cells on dry eye
disease pathogenesis have yet to be fully elucidated, but preliminary evidence suggests that
closed eye neutrophils may have an associated hyperactivity and increased degranulation in
dry eye disease that could contribute to epithelial instability. As an anti-T cell therapy,
Xiidra offers an opportunity to better understand how the closed eye white blood cells are
recruited and activated. This study also seeks to verify the proposed mechanism of action.