Effects of Weekly Dosing of D-cycloserine on Cognitive Function in Individuals With Schizophrenia

• Status: Completed
• Trial end date: 2007-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The study aims to assess the effects of single dose and repeated weekly dosing of 50mg d-cycloserine versus placebo on cognitive and memory functioning in schizophrenia patients. The study will also examine the effects of 50mg d-cycloserine on positive symptoms and negative symptoms, as well as assess tolerability and side-effects.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Massachusetts General Hospital
• Treatments: Cycloserine

Criteria

Inclusion Criteria:

1. Male or female

2. Age 18-65 years

3. Diagnosis of schizophrenia or schizoaffective disorder, depressed type

4. Stable dose of antipsychotic for at least 4 weeks.

5. Able to provide informed consent

6. Able to complete a cognitive battery

Exclusion Criteria:

1. Current treatment with clozapine

2. Dementia

3. Seizure disorder

4. Unstable medical illness

5. Active substance abuse

6. Pregnancy, nursing, or unwilling to use appropriate birth control measures during participation if female and fertile.