Effects of Varied Estrogen Doses on Endometrial Receptivity

• Status: Recruiting
• Trial end date: 0000-00-00
• Target enrollment: 30
• Participant gender: Female

Summary

This study will help determine the effect of varied estradiol levels on the uterine lining in healthy humans that are not undergoing a stimulated in vitro fertilization (IVF) cycle.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Reproductive Medicine Associates of New Jersey
• Treatments: Estradiol; Estradiol 17 beta-cypionate; Estradiol 3-benzoate; Estradiol valerate; Estrogens; Leuprolide; Polyestradiol phosphate; Progesterone
• Last Updated: 2016-06-21

Criteria

Inclusion Criteria:

• Regular menstrual cycles

• Age 18-50

• Normal Baseline ultrasound

• No intra-uterine procedures in prior 90 days

Exclusion Criteria:

• Any contraindications to undergoing estrogen stimulation of the endometrium

• Age ≥35 years and smoking ≥15 cigarettes per day

• Multiple risk factors for arterial cardiovascular disease (smoking, diabetes, and hypertension)

• Hypertension (systolic ≥140 mmHg or diastolic ≥90 mmHg)

• Venous thromboembolism (current or history of)

• Known thrombogenic mutations

• Known ischemic heart disease

• History of stroke

• Complicated valvular heart disease (pulmonary hypertension, risk for atrial fibrillation, history of subacute bacterial endocarditis)

• Systemic lupus erythematosus (positive or unknown antiphospholipid antibodies)

• Migraine with aura at any age

• Breast cancer

• Cirrhosis

• Hepatocellular adenoma or malignant hepatoma

• History of undiagnosed abnormal uterine bleeding.

• Allergic reaction to any study drug

• Known pregnancy or delivery within the past 6 months

• Breastfeeding

• Obesity >35 kg/m2