Effects of USP Methylene Blue on Cognitive and fMRI Brain Activity
Status:
Completed
Trial end date:
2016-03-01
Target enrollment:
Participant gender:
Summary
The purpose of the study is to evaluate whether low-dose USP methylene blue (MB) will: i)
improve short-term memory retention in a delayed match-to-sample task, ii) reduce reaction
time in a psychomotor vigilance test, and iii) enhance responses to a visual-motor task as
measured by functional magnetic resonance imaging (fMRI).
A single low-dose MB or placebo will be orally administered to self-declared healthy adults
using double-blind study design. Non-invasive fMRI data will be acquired before and after MB
administration in the same subjects. Each study will take 2-3 hours, inclusive of an hour
break in between.
Phase:
Early Phase 1
Details
Lead Sponsor:
The University of Texas Health Science Center at San Antonio Timothy Q. Duong